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ภาควิชาจุลชีววิทยา คณะวิทยาศาสตร์ จุฬาลงกรณ์มหาวิทยาลัย
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Academic Staff

Tanapat Palaga, Professor, Ph.D.

Tanapat Palaga, Professor, Ph.D.

Education

2002 Ph.D. in Microbiology/Immunology, University of Massachusetts Amherst, USA
1996 M. Eng. in Biotechnology, Tokyo Institute of Technology, Japan
1994 B. Eng. in Bioengineering, Tokyo Institute of Technology, Japan

Training

2009 Hitachi Research Fellowship, Department of Immunology and Parasitology, The University of Tokushima, Japan
2006 DAAD Research Fellow, Max-Plank Institute for Infection Biology, Germany
2002 Postdoctoral Fellow, Department of Veterinary and Animal Science, University Massachusetts Amherst, USA

Research Interest

– Signal transduction in innate immune cells in diseases and tissue homeostasis
– Epigenetics in innate immune memory
– Tumor-associated macrophages and cancer immunotherapy
– mRNA vaccine
– Immunology of tuberculosis

Publications

From Research gate Click
From Scopus Click
From Orcid Click
From Google Scholar Click

Selected Publications

  1. Palaga, T, Miele, L, Golde, TE and Osborne, BA. (2003). TCR-mediated Notch signaling regulates proliferation and IFN-g production in peripheral T cells. J. Immunol. 171, 3019-3024
  2. Minter, LM, Turley, DM, Das, P, Shin, HM, Joshi, I, Lawlor, RG, Cho, OH, Palaga, T, Gottipati, S., Telfer, JC, Kostura, L, Fauq, AH, Simpson, K, Such, KA, Miele, L, Golde, TE, Miller, SD, and Osborne BA. (2005). Inhibition of g-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21. Nat. Immunol. 6, 680-688
  3. Palaga, T, Buranaruk, C, Rengpipat, R, Fauq, AH, Golde, TE, Kaufmann, SHE, and Osborne, BA. (2008). Notch signaling is activated by TLR stimulation and regulates macrophage functions. Eur. J. Immunol. 38, 174-183.
  4. Suwanjunee, S, Wongchana, W, and Palaga, T. (2008) Inhibition of gamma-secretase affects proliferation of leukemia and hepatoma cell lines through Notch signaling. Anticancer Drug 19, 477-486.
  5. Sodsai, P, Avihingsanon, Y, Hirankarn, N, and Palaga, T. (2008). Defects in Notch1 upregulation upon activation of T cells from patients with systemic lupus erythematosus are related to lupus disease activity. Lupus 17, 645-653.
  6. Puwipirom, H, Hirankarn, N, Sodsai, P, Avihingsanon, Y, Wongpiyabovorn, J, and Palaga, T. (2010) Increased interleukin-23 receptor+ T cells in peripheral blood mononuclear cells of patients with systemic lupus erythematosus. Arthritis Res. Ther. 12, R215.
  7. Kuncharin, Y, Sangphech, N, Kueanjinda, P, Bhattarakosol, P and Palaga, T. (2011) MAML1 regulates cell viability via the NF-kB pathway in cervical cancer cell lines. Exp. Cell Res.
  8. Wongchana, W and Palaga, T. (2011) Direct regulation of interleukin-6 expression by Notch signaling in macrophages. Cell. Mol. Immunol. 8, 1-8.
  9. Wisutsitthiwong, C, Buranaruk, C, Pudhom, K and Palaga, T. (2011) The plant limonoid 7-oxo-deacetoxygedunin inhibits RANKL-induced osteoclastogenesis by suppressing activation of the NF-êB and MAPK pathways. Biochem. Biophys. Res. Commun. 415, 361-366.
  10. Boonyatecha, N, Sangphech, N, Wongchana, W, Kueanjinda, P and Palaga, T. (2012) Involvement of Notch signaling pathway in regulating IL-12 expression via c-Rel in activated macrophages. Mol. Immunol. 51, 255-62.
  11. Meerak, J, Wanichwecharungruang, SP and Palaga, T. (2013) Enhancement of immune response to a DNA vaccine against Mycobacterium tuberculosis Ag85B by incorporation of an autophagy inducing system. Vaccine 31, 784-790.
  12. Palaga, T, Ratanabunyong, S, Pattarakankul, T, Sangphech, N, Wongchana, W, Hadae, Y and Kuenjinda, P. (2013) Notch signaling regulates expression of Mcl-1 and apoptosis in PPD-treated macrophages. Cell. Mol. Immunol. 10, 444-52.
  13. Sangphech, N, Osborne, BA and Palaga, T. (2014) Notch signaling regulates the phosphorylation of Akt and survival of lipopolysaccharide-activated macrophages via regulator of G protein signaling 19 (RGS19). Immunobiology 219, 653-660.
  14. Umthong, S, Buaklin, A, Jacquet, A, Sangjun, N, Kerdkaew, R, Patarakul, K, and Palaga, T. (2015) Immunogenicity of a DNA and Recombinant Protein Vaccine Combining LipL32 and Loa22 for Leptospirosis Using Chitosan as a Delivery System. J Microbiol Biotechnol. 25, 526-536.
  15. Kueanjinda, P, Roytrakul, S, Palaga, T. A Novel Role of Numb as A Regulator of Pro-inflammatory Cytokine Production in Macrophages in Response to Toll-like Receptor 4. (2015) Sci Rep. 5, 12784.
  16. Wongchana W, Lawlor RG, Osborne BA, Palaga, T. Impact of Notch1 Deletion in Macrophages on Proinflammatory Cytokine Production and the Outcome of Experimental Autoimmune Encephalomyelitis. (2015) J Immunol. 195, 5337-5346.
  17. Kongkavitoon P, Tangkijvanich P, Hirankarn N and Palaga, T. Hepatitis B Virus HBx Activates Notch Signaling via Delta-like 4/Notch1 in Hepatocellular Carcinoma. (2016) PLoS One 11, e0146696.
  18. Chawalitpong, S, Sornkaew, N, Suksamrarn, A and Palaga, T. Diarylheptanoid from Curcumacomosa Roxb.suppresses RANKL-induces osteoclast differentiation by decreasing NFATc1 and c-Fos expression via MAPK pathway. (2016) Eur J Pharmaco. 788, 351–359.
  19. Ondee T, Surawut S, Taratummarat S, Hirankan N, Palaga T, Pisitkun P, Pisitkun T, Leelahavanichkul A. FC Gamma Receptor IIB Deficient Mice: A Lupus Model with Increased Endotoxin Tolerance-Related Sepsis Susceptibility. (2017) Shock. 47, 743-752.
  20. Surawut S, Ondee T, Taratummarat S, Palaga T, Pisitkun P, Chindamporn A, Leelahavanichkul A. The role of macrophages in the susceptibility of Fc gamma receptor IIb deficient mice to Cryptococcus neoformans. (2017) Sci Rep. 7, 40006.
  21. Palaga, T, Wongchana W, Kueanjinda P. Notch Signaling in Macrophages in the Context of Cancer Immunity. (2018) Front Immunol. 9, 652 (58).
  22. Chawalitpong S, Chokchaisiri R, Suksamrarn A, Katayama S, Mitani T, Nakamura S, Athamneh AA, Ritprajak P, Leelahavanichkul A, Aeimlapa R, Charoenphandhu N and Palaga T. Cyperenoic acid suppresses osteoclast differentiation and delays bone loss in a senile osteoporosis mouse model by inhibiting non-canonical NF-kB pathway. (2018) Sci Rep. 8(1), 5625.
  23. Wongchana W, Kongkavitoon P, Tangtanatakul P, Sittplangkoon C, Butta P, Chawalitpong S, Pattarakankul T, Osborne BA, Palaga, T. Notch signaling regulates the responses of lipopolysaccharide-stimulated macrophages in the presence of immune complexes. (2018) PLoS One, 13(6), e0198609.
  24. Kongkavitoon P, Butta P, Sanpavat A, Bhattarakosol P, Tangtanatakul P, Wongprom B, Tangkijvanich P, Hirankarn N, Palaga T. Regulation of periostin expression by Notch signaling in hepatocytes and liver cancer cell lines. (2018) Biochem Biophys Res Commun. 506(3):739-745.
  25. Sawutdeechaikul P, Cia F, Bancroft G, Wanichwecharungruang S, Sittplangkoon C, Palaga T. Oxidized carbon nanosphere-based subunit vaccine delivery system elicited robust Th1 and cytotoxic T cell responses. (2019) J Microbiol Biotechnol. 29(3):489-499.
  26. Sawutdeechaikul P, Jiangchareon B, Wanichwecharungruang S, Palaga T. Oxidized carbon nanoparticles as an effective protein antigen delivery system targeting the cell-mediated immune response. (2019) Int J Nanomedicine. 14:4867-4880.
  27. Ruenjaiman V, Butta P, Leu Y-W, Pongpanich M, Leelahavanichkul A, Kueanjinda P, Palaga T. Profile of Histone H3 Lysine 4 Trimethylation and the Effect of Lipopolysaccharide/Immune Complex-Activated Macrophages on Endotoxemia. (2020) Front Immunol. 10, 2956.
  28. Prompetchara E, Ketloy C, Palaga T. Immune responses in COVID-19 and potential vaccines: Lessons learned from SARS and MERS epidemic. Asian Pac J Allergy Immunol. 2020 Mar;38(1):1-9. doi: 10.12932/AP-200220-0772. PMID: 32105090.
  29. Sangphech N, Keawvilai P, Palaga T. Notch signaling increases PPARγ protein stability and enhances lipid uptake through AKT in IL-4-stimulated THP-1 and primary human macrophages. FEBS Open Bio. 2020 Jun;10(6):1082-1095.
  30. Songthammanuphap S, Puthong S, Pongma C, Buakeaw A, Prammananan T, Warit S, Tipkantha W, Kaewkhunjob E, Yindeeyoungyeon W, Palaga T. Detection of Mycobacterium tuberculosis complex infection in Asian elephants (Elephas maximus) using an interferon gamma release assay in a captive elephant herd. Sci Rep. 2020 Sep 3;10(1):14551.
  31. Warit S, Billamas P, Makhao N, Jaitrong S, Juthayothin T, Yindeeyoungyeon W, Dokladda K, Smittipat N, Kemthong T, Meesawat S, Kongsombat N, Kraitat C, Prammananan T, Palaga T, Chaiprasert A, Malaivijitnond S. Detection of tuberculosis in cynomolgus macaques (Macaca fascicularis) using a supplementary Monkey Interferon Gamma Releasing Assay (mIGRA). Sci Rep. 2020 Oct 7;10(1):16759.
  32. Techawiwattanaboon T, Barnier-Quer C, Palaga T, Jacquet A, Collin N, Sangjun N, Komanee P, Patarakul K. A Comparison of Intramuscular and Subcutaneous Administration of LigA Subunit Vaccine Adjuvanted with Neutral Liposomal Formulation Containing Monophosphoryl Lipid A and QS21. Vaccines (Basel). 2020 Sep 1;8(3):494.
  33. Jaroonwitchawan T, Visitchanakun P, Dang PC, Ritprajak P, Palaga T, Leelahavanichkul A. Dysregulation of Lipid Metabolism in Macrophages Is Responsible for Severe Endotoxin Tolerance in FcgRIIB-Deficient Lupus Mice. Front Immunol. 2020 Jun 9;11:959.
  34. Saenwongsa W, Nithichanon A, Chittaganpitch M, Buayai K, Kewcharoenwong C, Thumrongwilainet B, Butta P, Palaga T, Takahashi Y, Ato M, Lertmemongkolchai G. Metformin-induced suppression of IFN-α via mTORC1 signalling following seasonal vaccination is associated with impaired antibody responses in type 2 diabetes. Sci Rep. 2020 Feb 24;10(1):3229.

Grants, Awards and Recognition

2003 Research Grant from Asahi Glass Foundation
2004 Research Grant from Third World Academy of Science
2009 Research Grant from International Science Foundation
2009-2011 ​Research Grant from TRF for Mid-career University Faculty Staff (Thailand Research Fund, Thailand)
2009-2010 Global Challenge Explorations Grant from Bill & Melinda Gates Foundation (USA)
2010-2012 Fogarty International Research Collaborative Award (NIH, USA)
2010-2011 Research Grant from Nanotech (NSTDA, Thailand)
2012 The Taguchi Prize for Outstanding Research 2012, Thailand Society of Biotechnology, 2012
2020 The Newton Fund/Institutional Links (British Council, UK)
2020 Research Team Promotion Grant (National Research Council Thailand)