Microbiology
Department of Microbiology, Faculty of Science, Chulalongkorn University
Microbial Technology Service Center
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Tanapat Palaga, Professor, Ph.D.

Phone : 662 218 5095
 
Education
2009    Hitachi Research Fellowship, Department of Immunology and Parasitology, The    University of Tokushima, Japan
2006    DAAD Research Fellow, Max-Plank Institute for Infection Biology, Germany
2001    Postdoctoral Fellow, Department of Veterinary and Animal Science, University of                 Massachusetts Amherst, USA
2001    Ph.D. in Microbiology/Immunology, University of Massachusetts Amherst, USA
1996    M. Eng. in Biotechnology, Tokyo Institute of Technology, Japan    
1994    B. Eng. in Bioengineering, Tokyo Institute of Technology, Japan
 
 
Training
  1. Postdoctoral fellow (Immunology), U. of Massachusetts Amherst, USA (2002)
  2. DAAD Research Fellow Max Planck Institute for Infection Biology, Germany (2006)
 
Research Interest
- Signal transduction in innate immune cells and cancer cells
- Macrophages in obesity and cancer
- Immunotherapy for cancer
- Nanotechnology for vaccine
- Diagnosis and vaccine for tuberculosis
-Bioactive compounds for aging-associated diseases 
 
Publications from scopus

 
Other Publications
  1. Faksri, K, Chaiprasert, A, Pardieu, C, Casali, N, Palaga, T, Prammananan, T, Palittapongarnpim, P, Prayoonwiwat, N and Drobniewski, F. (2014) Heterogeneity of phenotypic characteristics of the modern and ancestral Beijing strains of Mycobacterium tuberculosis. Asian Pac J Allergy Immunol. 32, 124-132. (IF=1.25)
  2. Anuleejun, S, Palaga, T, Katakura, Y, Kuroki, M, Kuroki M and Napathorn, SC. (2014) Optimal production of a fusion protein consisting of a single-chain variable fragment antibody against a tumor-associated antigen and interleukin-2 in fed-batch culture of Pichia pastoris. Anticancer Res. 34, 3925-35. (IF=1.872)
  3. Buaklin, A, Palaga, T, Hannaman, D, Kerdkaew, R, Patarakul, K and Jacquet A. (2014) Optimization of the immunogenicity of a DNA vaccine encoding a bacterial outer membrane lipoprotein. Mol. Biotech. 56, 903-910 (IF=2.275)
  4. Sangphech, N, Osborne, BA, Palaga, T. (2014) Notch signaling regulates the phosphorylation of Akt and survival of lipopolysaccharide-activated macrophages via regulator of G protein signaling 19 (RGS19). Immunobiology 219, 653-660  (accepted) (IF=3.108)
  5. Sangthong, S, Sangphech, N, Palaga, T, Ngamrojanavanich, N, Puthong, S, Vilaivan, T, Muangsin, N. (2014) Anthracene-9, 10-dione derivatives induced apoptosis in human cervical cancer cell line (CaSki) by interfering with HPV E6 expression. Eur. J. Med. Chem. 77, 334-342 (IF=3.432)
  6. Wongtangprasert, T, Natakuathung, W, Pimpitak, U, Buakeaw, A, Palaga, T, Komolpis, K, Khongchareonporn, N. (2014) Production of a monoclonal antibody against oxytetracycline and its application for oxytetracycline residue detection in shrimp. J Zhejiang UnivSci B. 15, 165-72. (IF=1.292)
  7. Palaga, T, Ratanabunyong, S, Pattarakankul, T, Sangphech, N, Wongchana, W, Hadae, Y, Kuenjinda, P. (2013) Notch signaling regulates expression of Mcl-1 and apoptosis in PPD-treated macrophages. Cell. Mol. Immunol.10, 444-52 (IF=4.158)
  8. Chadseesuwan, U, Puthong, S, Gajanandana, O, Palaga, T, Komolpis, K. (2013) Development of an enzyme-linked immunosorbent assay for 1-aminohydantoin detection. J. AOAC Int. 96, 1-8 (IF=1.23)
  9. Chusri, M, Wongphanit, P, Palaga, T, Puthong, S, Sooksai, S, Komolpis, K. (2013) Production and characterization of a monoclonal antibody against enrofloxacin. J. Microbiol. Biotechnol. 23, 65-75. (IF=1.40)
  10. Meerak, J, Wanichwecharungruang, SP, Palaga, T. (2013) Enhancement of immune response to a DNA vaccine against Mycobacterium tuberculosis Ag85B by incorporation of an autophagy inducing system. Vaccine 31, 784-790. (IF=3.485)
  11. Osathanon, T, Manokawinchoke, J, Nowwarote, N, Aguilar, P, Palaga, T, Pavasant, P. Notch signaling is involved in neurogenic commitment of human periodontal ligament-derived mesenchymal stem cells. Stem Cells Dev. 2013 (in press). (IF=4.202)
  12. Palaga, T and Minter, LM. (2012) Notch signaling and its emerging role in autoimmunity. Front. Biol. DOI 10.1007/s11515-012-1209-z.
  13. Boonyatecha, N, Sangphech, N, Wongchana, W, Kueanjinda, P and Palaga, T. (2012) Involvement of Notch signaling pathway in regulating IL-12 expression via c-Rel in activated macrophages. Mol. Immunol. 51, 255-62. (IF=3.003)
  14. Arayachukeat S, Palaga, T and Wanichwecharungruang SP. (2012) Clusters of carbon nanospheres derived from graphene oxide. ACS Appl. Mater. Interfaces. 4, 6808-15. (IF=5.900)
  15. Wisutsitthiwong, C, Buranaruk, C, Pudhom, K, Palaga, T. (2011) The plant limonoid 7-oxo-deacetoxygedunin inhibits RANKL-induced osteoclastogenesis by suppressing activation of the NF-kappaB and MAPK pathways. Biochem. Biophys. Res. Commun. 415, 361-366. (IF=2.595)
  16. Wongchana, W, Palaga, T. (2011) Direct regulation of interleukin-6 expression by Notch signaling in macrophages. Cell. Mol. Immunol. 8, 1-8. (IF=4.158)
  17. Yorsangsukkamol, J, Chaiprasert, A, Palaga, T, Prammananan, T, Faksri, K, Palittapongarnpim, P, Prayoonwiwat, N. (2011) Apoptosis, production of MMP9, VEGF, TNF-a and intracellular growth of M. tuberculosis for different genotypes and different pks15/1 genes. Asia. Pac. J. Aller. Immunol. 29, 1-13. (IF=1.25)
  18. Ravangpai, W, Sommit, D, Teerawatananond, T, Sinpranee, N, Palaga, T, Pengpreecha, S, Muangsin, N, Pudhom, K. (2011) Limonoids from seeds of Thai Xylocarpusmoluccensis. Bioorg. Med. Chem. Lett. 21, 4485-4489. (IF=2.661)
  19. Kuncharin, Y, Sangphech, N, Kueanjinda, P, Bhattarakosol, P, Palaga, T. (2011) MAML1 regulates cell viability via the NF-kB pathway in cervical cancer cell lines. Exp. Cell Res. 317, 1830-1840. (IF=3.372)
  20. Puwipirom, H., Hirankarn, N., Sodsai, P., Avihingsanon, Y., Wongpiyabovorn, J., and Palaga, T. (2010) Increased interleukin-23 receptor+ T cells in peripheral blood mononuclear cells of patients with systemic lupus erythematosus. Art. Res. Ther. 12, R215. (IF=4.12) 
  21. Kammarnjesadakul, P., Palaga, T., Sritunyalucksana, K., Mendoza, L., Krajaejun, T., Vanittanakom, N., Tongchusak, S., Denduangboripant, J., Chindamporn, A. (2010) Phylogenetic analysis of Pythium insidiosum Thai strains using cytochrome oxidase II (COXII) DNA coding sequences and internal transcribed spacer regions (ITS). Med. Mycol. 49, 289-295. (IF = 2.261)
  22. Wangthong, S., Palaga, T., Rengpipat, S., Wanichwecharungruang, SP., Chanchaisak, P. and Heinrich, M. (2010) Biological activities and safety of Thanaka (Hesperethusacrenulata) stem bark. J. Ethnopharmacol. 132, 466-472. (IF=2.322)
  23. Wittayasuporn, M, Rengpipat, S, Palaga, T, Asawanonda, P, Anumansirikul, N, and Wanichwecharungruang, SP. (2010) Chitosan derivative nanocarrier: Safety evaluation, antibacterial property and ascorbylpalmitate encapsulation. J. Microencapsul. 27, 218-225. (IF=1.314)
  24. Pimpitak, U, Putong, S, Komolpis, K, Petsom, A, and Palaga, T. (2009) Development of a monoclonal antibody-based enzyme-linked immunosorbent assay for detection of the furaltadone metabolite, AMOZ, in fortified shrimp samples. Food Chem. 116, 785-791. (IF=3.259)
  25. Palaga, T. (2009) Update on the Immunology of Tuberculosis. Siriraj Med. J. 61, 37-41.
  26. Rengpipat, S, Wongtangprasert, N, and Palaga, T. (2008) The use of green fluorescent protein as a marker for monitoring a probiotic Bacillus S11 in the black tiger shrimp Penaeus monodon. Aquacult. Nutr., 15, 297-305. (IF=1.398)
  27. Sodsai, P, Avihingsanon, Y, Hirankarn, N, and Palaga, T. (2008). Defects in Notch1 upregulation upon activation of T cells from patients with systemic lupus erythematosus are related to lupus disease activity. Lupus 17, 645-653. (IF=2.244)
  28. Suwanjunee, S, Wongchana, W, and Palaga, T. (2008) Inhibition of gamma-secretase affects proliferation of leukemia and hepatoma cell lines through Notch signaling. Anticancer Drug 19, 477-486. (IF=2.358)
  29. Palaga, T, Buranaruk, C, Rengpipat, R, Fauq, AH, Golde, TE, Kaufmann, SHE, and Osborne, BA. (2008). Notch signaling is activated by TLR stimulation and regulates macrophage functions. Eur. J. Immunol.38, 174-183. (IF=4.865)
  30. Monhaphol, T, Yibchok-anun, S, Banlunara, W, Wittayasuporn, M, Palaga, T, Asawanonda, P and Wanichweacharungruang, S. (2008) Cytotoxicity, acute oral toxicity and skin irritation of 2-ethylhexyl-2,4,5 trimethoxycinnamate and di(2-ethylhexyl)-2,4,5 trimethoxybenzalmalonate. Drug. Chem. Toxico.31, 289-301. (IF=1.239)
  31. Minter, LM, Turley, DM, Das, P, Shin, HM, Joshi, I, Lawlor, RG, Cho, OH, Palaga, T, Gottipati, S., Telfer, JC, Kostura, L, Fauq, AH, Simpson, K, Such, KA, Miele, L, Golde, TE, Miller, SD, and Osborne BA. (2005). Inhibition of g-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21. Nat. Immunol. 6, 680-688. (IF=27.596)
  32. Palaga, T. (2004). Nuclear Hormone Receptor, Apoptosis and Notch: A lesson from an immune system.Sci. Res. Chula. 29, 129-144.
  33. Palaga, T, Kataoka, T, and Nagai, K. (2004). Extracellular ATP inhibits apoptosis and maintains cell viability by inducing autocrine production of interleukin 4. Int. Immunopharmaco. 4, 953-961. (IF=2.157)
  34. Palaga, T, Miele, L, Golde, TE and Osborne, BA. (2003). TCR-mediated Notch signaling regulates proliferation and IFN-g production in peripheral T cells. J. Immunol. 171, 3019-3024. (IF=6.239)
  35. Palaga, T, and Osborne, BA. (2002). The 3D’s of apoptosis: death, degradation and DIAPs. Nature Cell Biol. 4, E149-151. (IF=17.623)
  36. Palaga, T, Kataoka, T, Woo, J-T, and Nagai, K. (1996). Suppression of apoptotic cell death of IL-3-dependent cell lines by ER/SR Ca2+-ATPase inhibitors upon IL-3 deprivation. Exp. Cell Res. 228, 92-97. (IF=3.777)
 
Grants, Awards and Recognition
2003        
Research Grant from Asahi Glass Foundation
2004        
Research Grant from Third World Academy of Science
2006-2008
Research Grant from Thailand Research Fund (TRF) for New University Faculty Staff
2009      
Government Annual Budget
2009        
Research Grant from International Science Foundation
2009-2011
Research Grant from TRF for Mid-career University Faculty Satff
2009-2010
Global Challenge Explorations Grant from Bill & Melinda Gates Foundation (USA)
2010-2012
Fogarty International Research Collaborative Award (NIH, USA)
2010-2011
Research Grant from Nanotech (NSTDA)
2006        
Young Faculty Award in Biological Sciences, Faculty of Science, Chulalongkorn   University
2009        
Faculty of Science (Chulalongkorn University) Echo Award 
2012
The Taguchi Prize for Outstanding Research 2012, Thailand Society of Biotechnology, 2012

 

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